18F-FDG PET-CT in a reumatoid arthritis model

A20 (TNFAIP3) is a protein that is involved in the negative feedback regulation of NF-KB signaling in response to specific proinflammatory stimuli in different cell types and has been suggested as a succeptibility gene for rheumatoid arthritis. Van Loo et al. demonstrated a critical and cell-specific function for A20 in the etiology of rheumatoid arthritis, by generating a myeloid-specific A20-deficient mouse model (Van Loo et al., 2014. Nature Genetics).

18F-FDG PET-CT was used to demonstrate inflammation in the paws of myeloid-A20-deficient mice.

Courtesy of Van Loo et al., Center for Inflammation Research – VIB, Ghent.