Dose reduction study with 99mTc-DMSA

In this application we show the use of our γ-CUBE. The high-sensitivity, high-resolution SPECT imager allowing whole-body mouse and rat imaging. 99mTc-DMSA is a SPECT tracer that is taken up in the cortex of the kidneys, and is used to assess renal function.

Here we used this tracer to perform a SPECT dose reduction study. A mouse was injected with 24 MBq 99mTc-DMSA and was scanned 4 hours post injection. The GP mouse collimator was used with a scan protocol of 30 minutes and data was reconstructed at a 500 µm voxel size. Data reduction was used during reconstruction, to correspond with different injected doses (ranging from 24 to 2.4 MBq). A general purpose CT scan was consequently taken using the X-CUBE, for anatomical correlation.

The image below shows that at severely reduced activity the uptake and image quality remains. This shows the γ-CUBE is both a high-sensivity as high-resolution multi-purpose system.