February 25, 2021
Arthritis Research and Therapy publication: Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis
In this paper by Christodoulou-Vafeiadou et al., the MOLECUBES X-CUBE was used to investigate whether the TgA89 mouse model reproduces key pathological features of human spondylitis including axial and peripheral ectopic bone formation and systemic bone loss.
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October 5, 2020
Cardiac gated PET imaging in mouse and rat
In the examples below, a rat and mouse were injected with 17 and 8.8 MBq, respectively, of [18F]-FDG ± 80 minutes prior to cardiac gated PET scanning (dose at start scan: 10.2 and 5.5 MBq, respectively). For each cardiac cycle, 8 gates were defined and for each gate a PET image was reconstructed using the OSEM algorithm with default settings as provided by the Molecubes software
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October 2, 2020
I124 PET imaging in nanomedicine
In the example below I-124 was coupled to an enzymatic nanomotor in order to better understand their behaviour in vivo and this way further enhance drug delivery efficiency compared to passive particles. Courtesy of Ana C. Hortelao, CICBiomaGUNE.
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October 2, 2020
Acta Biomaterialia publication: In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT
In this paper by Kollenda et al., the MOLECUBES β-CUBE and X-CUBE were used to compare the biodistribution of 68Ga-labelled nanoparticles following different application routes: intravenous, intramuscular, intratumoral, and into soft tissue.
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August 28, 2020
Press Release: Indiana University School of Medicine chooses MOLECUBES to accelerate their research supporting the MODEL-AD and TREAD-AD Open Science Grants.
MOLECUBES NV, in partnership with LabLogic Systems Inc., has recently installed a β-X-CUBE imaging platform in the lab of Prof. Paul R. Territo at the Indiana University School of Medicine for their research supporting the MODEL-AD and TREAT-AD grants provided by NIH/NIA as consortium open science grants.
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June 5, 2020
Enabling µCT as a tool in biosafety cabinets and BSL 3 environments
MOLECUBES recently moved their X-CUBE installed at MOSAIC, KULEUVEN to the REGA institute to accelerate their world leading covid-19 research program. Thanks to the unique compact footprint in combination with a plug and play approach, the system was transported from the preclinical imaging lab and operational in the BSL3 lab in half a day.
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April 21, 2020
Scientific Reports publication: Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography
MOLECUBES X-CUBE study to understand the effect of gold nanoparticle size on CT contrast generation.
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April 21, 2020
Molecular Therapy publication: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene
In this study, the MOLECUBES β-CUBE and X-CUBE were used to investigate the ability of [18F]-TMP, a newly developed fluorine-18 probe, to image primary human chimeric antigen receptor (CAR) T cells expressing the PET reporter gene eDHFR.
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April 21, 2020
Clinical Cancer Research publication: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [18F]FLT and [18F]ISO-1 PET/CT
In this study, the MOLECUBES β-CUBE and X-CUBE were used to evaluate the performance of [18F]FLT and [18F]ISO-1 PET in predicting response to cell-cycle targeted treatment in estrogen receptor positive metastatic breast cancer.
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April 21, 2020
Nanoscale publication: PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities
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March 16, 2020
Free Radical Research publication: S-nitrosylated l-serine-modified dendrimer as a kidney-targeting nitric oxide donor for prevention of renal ischaemia/reperfusion injury
γ-CUBE and X-CUBE were used to investigate the preventive effect of SNO-Ser-PAMAM on renal ischaemia/reperfusion injury
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March 11, 2020
PET/PET/CT at KULEUVEN
The Molecular Small Animal Imaging Center core facility (MoSAIC) at KU Leuven has significantly expanded its preclinical PET capability with a PET PET CT setup from MOLECUBES
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March 9, 2020
Imaging heart remodelling with [99mTc]MIBI in a rat model for stroke
cardiac imaging using SPECT
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March 9, 2020
Visualising the striatum with [123I]FP-CIT SPECT imaging
striata of a mouse brain with SPECT
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February 19, 2020
EANM2019 Abstract: Radiofluorinated gases as regional ventilation markers – Application to a rat model of acute lung inflammation
Radiofluorinated gases as regional ventilation markers - Application to a rat model of acute lung inflammation
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February 19, 2020
Evaluation of the biodistribution of [18F]-labeled carbon dots
Carbon dots are spherical, nontoxic, biocompatible and discrete particles that have gained tremendous interest over the last years because of their ultra-compact nanosize, favourable biocompatibility and versatile surface engineering properties. They show significant potential for use in cellular imaging, biosensing, targeted drug delivery, theranostics and other biomedical applications.
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February 18, 2020
Quantitative cardiac gated PET imaging
In cardiac research, non-invasive measurement of left ventricular end-systolic (ESV), end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) is a useful tool to evaluate and monitor cardiac function in health and disease.
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November 20, 2019
MOLECUBES Webinar – 11th of December 2019 – 16:00 CET
MOLECUBES Webinar December 2019 - Positive Impact of High Throughput Imaging on Preclinical Research - Dr. Unai Cossío will present on ongoing research at CIC biomaGUNE
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July 24, 2019
PET/CT at Ospedale San Raffaele
MOLECUBES and Radius have recently installed a preclinical benchtop whole body rat PET/CT in Milan (Italy) at San Raffaele Hospital and Scientific Institute, as a joint collaboration among the Institute of Molecular Bioimaging and Physiology of the Italian National Research Council (IBFM-CNR), San Raffaele Hospital and the Department of Medicine and Surgery of the University of Milan Bicocca.
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June 7, 2019
PET/SPECT/CT at Wiener Neustadt
MOLECUBES and Oncomed Solutions have recently installed a trimodal PET/SPECT/CT whole body rat and mouse benchtop preclinical imaging system at the University of Applied Sciences Wiener Neustadt, Austria.
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June 5, 2019
PET/SPECT/CT at CIC biomaGUNE
MOLECUBES installed a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at CIC biomaGUNE, San Sebastian, Spain.
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October 25, 2018
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
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October 25, 2018
β-CUBE at the University Hospital Basel
β-CUBE at the University Hospital Basel
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October 25, 2018
PET/SPECT/CT at University of Liverpool
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Liverpool
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October 12, 2018
Zebrafish PET-CT imaging
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October 12, 2018
Detection of atherosclerotic plaque inflammation with nanobodies – Need for high sensitivity and resolution
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October 12, 2018
Mouse femur imaging
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October 12, 2018
SPECT-CT imaging to monitor bone healing
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September 10, 2018
MOLECUBES installs SPECT CT at KPU, Japan
MOLECUBES has recently installed a SPECT/CT imaging solution at the Radioisotope Research Center of Kyoto Pharmaceutical University.
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September 7, 2018
18F-FDG PET-CT in a reumatoid arthritis model
18F-FDG PET-CT in a reumatoid arthritis model
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September 7, 2018
Brain imaging in rats and mice
PET-MR imaging provides unique and complimentary functional and anatomical information. The exceptional sensitivity of PET, combined with the excellent soft tissue contrast provided by MRI can be particularly beneficial when quantification of the PET signal requires delineating volumes of interest in an area where the CT image does not provide sufficient tissue contrast, e.g. in neurology applications.
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April 16, 2018
Lung imaging with SPECT-CT
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April 16, 2018
EMIM 2018 abstract: Nanoparticle imaging with CT
The aim of this study was to quantify x-ray image contrast induction that result from gold nanoparticles imaging.
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January 12, 2018
Biomaterials publication: Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
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November 29, 2017
In vivo visualisation of vessel formation in peritoneal tumor scaffolds with µCT – poster EMIM 2017
To study drug penetration and its influencing factors, reliable in vivo models that mimic peritoneal carcinomatosis are crucial. By applying tissue engineering we successfully biomimicked a peritoneal ovarian tumor and its environment in mice. Functional blood vessel formation was evaluated with contrast enhanced µCT.
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October 16, 2017
Thyroid imaging in mice
Radioiodine accumulation in thyroid tissues are well-established tools for managing patients with thyroid disease
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October 16, 2017
Low dose PET
The β-CUBE is able to detect very low levels of radioactivity, which can be important for evaluation of new PET radiotracers that were synthesised with a low radiochemical yield or low specific activity
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August 21, 2017
Application note: Influence of animal handling on [18F]FDG uptake
It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.
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August 18, 2017
Testimonial Prof. Dr. Joel Karp (USA)
The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.
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August 9, 2017
MOLECUBES SPECT/CT at BET Solutions, Athens, Greece
MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.
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August 1, 2017
Small footprint/high throughput: multiple mouse PET-CT imaging
High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.
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July 3, 2017
MOLECUBES PET/SPECT/CT at University of Chicago, USA
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.
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June 16, 2017
CT protocol comparison
Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface.
During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.
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June 6, 2017
The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)
To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.
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June 5, 2017
Dynamic 18F-FCA PET-CT in a mouse
18F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury
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June 2, 2017
Dynamic 18F-FDG PET-MR in a glioblastoma rat model
In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.
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June 1, 2017
Contrast enhanced CT to detect liver tumors in a HCC mouse model
The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.
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May 29, 2017
Multimodal imaging in an experimental rat model for brain metastasis (EMIM, 2017)
Metastatic brain tumors are a severe problem in the treatment of patients with breast carcinoma. We developed a rat model for brain metastasis that allows follow-up by MRI. Injection of cancer cells labeled with iron oxide particles, allows tracking from the single-cell stage until the appearance of full-blown metastases.
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May 25, 2017
MOLECUBES PET/CT at Universitätsklinikum Essen, Germany
MOLECUBES will install its PET/CT full body rat and mouse benchtop system at Universitätsklinikum Essen, Germany in the Preclinical Imaging Laboratory of Prof. Ken Herrmann.
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May 17, 2017
MOLECUBES SPECT/CT at Uniklinik RWTH Aachen, Germany
MOLECUBES will install a SPECT/CT full body rat and mouse benchtop combination at the Uniklinik RWTH Aachen, Germany in the preclinical imaging laboratory of Prof. Felix Mottaghy
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May 3, 2017
Data based cardiac gating in rats and mice
During data-based cardiac gating available on the X-CUBE, the cardiac signal is derived from the data itself.
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April 29, 2017
Low dose 18F-NaF PET in mice
This application shows the possibility for full-body low-dow mouse PET-scanning on the β-CUBE.
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March 12, 2017
Dose reduction study with 99mTc-DMSA
In this application we show the use of our γ-CUBE. The high-sensitivity, high-resolution SPECT imager allowing whole-body mouse and rat imaging. 99mTc-DMSA is a SPECT tracer that is taken up in the cortex of the kidneys, and is used to assess renal function.
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March 2, 2017
Lung volume segmentation in mice
In this study, data based respiratory gated was performed after a high resolution CT acquisition. The end-enhalation and end-exhalation phases of the respiratory cycle were reconstructed.
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January 31, 2017
MOLECUBES PET/CT at UPENN, Philadelphia, USA
MOLECUBES has installed a PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN) at the lab of Prof. Joel Karp.
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January 1, 2017
Testimonial Prof. Dr. Christian Vanhove (BE)
Prof. Christian Vanhove is responsible for the day-to-day functioning of the preclinical INFINITY lab (Ghent, Belgium) and the coordination of the partner research, either from within Ghent University, from private pharma or biotech companies.
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May 29, 2016
MOLECUBES PET/SPECT/CT at Ghent University, Belgium
MOLECUBES has installed a PET/SPECT/CT benchtop combination at Ghent University's preclinical imaging lab, INFINITY. The lab is run by Prof. Christian Vanhove, is a consortium of research laboratories of the UGent University.
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October 25, 2015
Gamma-cube and X-cube: A New Scanner Generation for Benchtop Small Animal SPECT/CT (EANM, 2015)
The first generation small animal imaging systems offer molecular 3D imaging at sub millimetre spatial resolution with SPECT and sensitivities in the order of several percents using PET. These systems often occupy a whole room because they are based on large to medium-size detector technology, borrowed from clinical scanners.
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