April 2, 2021

Radiation Physics and Chemistry Publication: Direct proton range verification using oxygen-18 enriched water as a contrast agent

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April 2, 2021

Journal of Neuroscience publication: Seasonal Variation in the Brain µ-Opioid Receptor Availability

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March 23, 2021

ACS Applied Nano Materials publication: Radiolabeled Cobaltabis(dicarbollide) Anion−Graphene Oxide Nanocomposites for In Vivo Bioimaging and Boron Delivery

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March 12, 2021

ACS Nano publication: Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease

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March 5, 2021

EJNMM publication: Evaluation of [18F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

This study aimed to evaluate whether N,N- diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).

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February 25, 2021

Arthritis Research and Therapy publication: Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis

In this paper by Christodoulou-Vafeiadou et al., the MOLECUBES X-CUBE was used to investigate whether the TgA89 mouse model reproduces key pathological features of human spondylitis including axial and peripheral ectopic bone formation and systemic bone loss.

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October 5, 2020

Cardiac gated PET imaging in mouse and rat

In the examples below, a rat and mouse were injected with 17 and 8.8 MBq, respectively, of [18F]-FDG ± 80 minutes prior to cardiac gated PET scanning (dose at start scan: 10.2 and 5.5 MBq, respectively). For each cardiac cycle, 8 gates were defined and for each gate a PET image was reconstructed using the OSEM algorithm with default settings as provided by the Molecubes software

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October 2, 2020

I124 PET imaging in nanomedicine

In the example below I-124 was coupled to an enzymatic nanomotor in order to better understand their behaviour in vivo and this way further enhance drug delivery efficiency compared to passive particles. Courtesy of Ana C. Hortelao, CICBiomaGUNE.

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October 2, 2020

Acta Biomaterialia publication: In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT

In this paper by Kollenda et al., the MOLECUBES β-CUBE and X-CUBE were used to compare the biodistribution of 68Ga-labelled nanoparticles following different application routes: intravenous, intramuscular, intratumoral, and into soft tissue.

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August 28, 2020

Press Release: Indiana University School of Medicine chooses MOLECUBES to accelerate their research supporting the MODEL-AD and TREAD-AD Open Science Grants.

MOLECUBES NV, in partnership with LabLogic Systems Inc., has recently installed a β-X-CUBE imaging platform in the lab of Prof. Paul R. Territo at the Indiana University School of Medicine for their research supporting the MODEL-AD and TREAT-AD grants provided by NIH/NIA as consortium open science grants.

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June 5, 2020

Enabling µCT as a tool in biosafety cabinets and BSL 3 environments

MOLECUBES recently moved their X-CUBE installed at MOSAIC, KULEUVEN to the REGA institute to accelerate their world leading covid-19 research program. Thanks to the unique compact footprint in combination with a plug and play approach, the system was transported from the preclinical imaging lab and operational in the BSL3 lab in half a day.

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April 21, 2020

Scientific Reports publication: Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography

MOLECUBES X-CUBE study to understand the effect of gold nanoparticle size on CT contrast generation.

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April 21, 2020

Molecular Therapy publication: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene

In this study, the MOLECUBES β-CUBE and X-CUBE were used to investigate the ability of [18F]-TMP, a newly developed fluorine-18 probe, to image primary human chimeric antigen receptor (CAR) T cells expressing the PET reporter gene eDHFR.

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April 21, 2020

Clinical Cancer Research publication: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [18F]FLT and [18F]ISO-1 PET/CT

In this study, the MOLECUBES β-CUBE and X-CUBE were used to evaluate the performance of [18F]FLT and [18F]ISO-1 PET in predicting response to cell-cycle targeted treatment in estrogen receptor positive metastatic breast cancer.

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April 21, 2020

Nanoscale publication: PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities

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March 16, 2020

Free Radical Research publication: S-nitrosylated l-serine-modified dendrimer as a kidney-targeting nitric oxide donor for prevention of renal ischaemia/reperfusion injury

γ-CUBE and X-CUBE were used to investigate the preventive effect of SNO-Ser-PAMAM on renal ischaemia/reperfusion injury

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March 11, 2020

PET/PET/CT at KULEUVEN

The Molecular Small Animal Imaging Center core facility (MoSAIC) at KU Leuven has significantly expanded its preclinical PET capability with a PET PET CT setup from MOLECUBES

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March 9, 2020

Imaging heart remodelling with [99mTc]MIBI in a rat model for stroke

cardiac imaging using SPECT

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March 9, 2020

Visualising the striatum with [123I]FP-CIT SPECT imaging

striata of a mouse brain with SPECT

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February 19, 2020

EANM2019 Abstract: Radiofluorinated gases as regional ventilation markers – Application to a rat model of acute lung inflammation

Radiofluorinated gases as regional ventilation markers - Application to a rat model of acute lung inflammation

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February 19, 2020

Evaluation of the biodistribution of [18F]-labeled carbon dots

Carbon dots are spherical, nontoxic, biocompatible and discrete particles that have gained tremendous interest over the last years because of their ultra-compact nanosize, favourable biocompatibility and versatile surface engineering properties. They show significant potential for use in cellular imaging, biosensing, targeted drug delivery, theranostics and other biomedical applications.

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February 18, 2020

Quantitative cardiac gated PET imaging

In cardiac research, non-invasive measurement of left ventricular end-systolic (ESV), end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) is a useful tool to evaluate and monitor cardiac function in health and disease.

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November 20, 2019

MOLECUBES Webinar – 11th of December 2019 – 16:00 CET

MOLECUBES Webinar December 2019 - Positive Impact of High Throughput Imaging on Preclinical Research - Dr. Unai Cossío will present on ongoing research at CIC biomaGUNE

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July 24, 2019

PET/CT at Ospedale San Raffaele

MOLECUBES and Radius have recently installed a preclinical benchtop whole body rat PET/CT in Milan (Italy) at San Raffaele Hospital and Scientific Institute, as a joint collaboration among the Institute of Molecular Bioimaging and Physiology of the Italian National Research Council (IBFM-CNR), San Raffaele Hospital and the Department of Medicine and Surgery of the University of Milan Bicocca.

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June 7, 2019

PET/SPECT/CT at Wiener Neustadt

MOLECUBES and Oncomed Solutions have recently installed a trimodal PET/SPECT/CT whole body rat and mouse benchtop preclinical imaging system at the University of Applied Sciences Wiener Neustadt, Austria.

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June 5, 2019

PET/SPECT/CT at CIC biomaGUNE

MOLECUBES installed a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at CIC biomaGUNE, San Sebastian, Spain.

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October 25, 2018

PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)

PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)

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October 25, 2018

β-CUBE at the University Hospital Basel

β-CUBE at the University Hospital Basel

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October 25, 2018

PET/SPECT/CT at University of Liverpool

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Liverpool

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October 12, 2018

Zebrafish PET-CT imaging

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October 12, 2018

Detection of atherosclerotic plaque inflammation with nanobodies – Need for high sensitivity and resolution

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October 12, 2018

Mouse femur imaging

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October 12, 2018

SPECT-CT imaging to monitor bone healing

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September 10, 2018

MOLECUBES installs SPECT CT at KPU, Japan

MOLECUBES has recently installed a SPECT/CT imaging solution at the Radioisotope Research Center of Kyoto Pharmaceutical University.

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September 7, 2018

18F-FDG PET-CT in a reumatoid arthritis model

18F-FDG PET-CT in a reumatoid arthritis model

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September 7, 2018

Brain imaging in rats and mice

PET-MR imaging provides unique and complimentary functional and anatomical information. The exceptional sensitivity of PET, combined with the excellent soft tissue contrast provided by MRI can be particularly beneficial when quantification of the PET signal requires delineating volumes of interest in an area where the CT image does not provide sufficient tissue contrast, e.g. in neurology applications.

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April 16, 2018

Lung imaging with SPECT-CT

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April 16, 2018

EMIM 2018 abstract: Nanoparticle imaging with CT

The aim of this study was to quantify x-ray image contrast induction that result from gold nanoparticles imaging.

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January 12, 2018

Biomaterials publication: Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

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November 29, 2017

In vivo visualisation of vessel formation in peritoneal tumor scaffolds with µCT – poster EMIM 2017

To study drug penetration and its influencing factors, reliable in vivo models that mimic peritoneal carcinomatosis are crucial. By applying tissue engineering we successfully biomimicked a peritoneal ovarian tumor and its environment in mice. Functional blood vessel formation was evaluated with contrast enhanced µCT.

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October 16, 2017

Thyroid imaging in mice

Radioiodine accumulation in thyroid tissues are well-established tools for managing patients with thyroid disease

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October 16, 2017

Low dose PET

The β-CUBE is able to detect very low levels of radioactivity, which can be important for evaluation of new PET radiotracers that were synthesised with a low radiochemical yield or low specific activity

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August 21, 2017

Application note: Influence of animal handling on [18F]FDG uptake

It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.

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August 18, 2017

Testimonial Prof. Dr. Joel Karp (USA)

The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.

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August 9, 2017

MOLECUBES SPECT/CT at BET Solutions, Athens, Greece

MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.

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August 1, 2017

Small footprint/high throughput: multiple mouse PET-CT imaging

High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.

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July 3, 2017

MOLECUBES PET/SPECT/CT at University of Chicago, USA

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.

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June 16, 2017

CT protocol comparison

Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface. During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.

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June 6, 2017

The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)

To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.

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June 5, 2017

Dynamic ¹⁸F-FCA PET-CT in a mouse

¹⁸F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury

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June 2, 2017

Dynamic ¹⁸F-FDG PET-MR in a glioblastoma rat model

In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.

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June 1, 2017

Contrast enhanced CT to detect liver tumors in a HCC mouse model

The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.

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May 29, 2017

Multimodal imaging in an experimental rat model for brain metastasis (EMIM, 2017)

Metastatic brain tumors are a severe problem in the treatment of patients with breast carcinoma. We developed a rat model for brain metastasis that allows follow-up by MRI. Injection of cancer cells labeled with iron oxide particles, allows tracking from the single-cell stage until the appearance of full-blown metastases.

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May 25, 2017

MOLECUBES PET/CT at Universitätsklinikum Essen, Germany

MOLECUBES will install its PET/CT full body rat and mouse benchtop system at Universitätsklinikum Essen, Germany in the Preclinical Imaging Laboratory of Prof. Ken Herrmann.

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May 17, 2017

MOLECUBES SPECT/CT at Uniklinik RWTH Aachen, Germany

MOLECUBES will install a SPECT/CT full body rat and mouse benchtop combination at the Uniklinik RWTH Aachen, Germany in the preclinical imaging laboratory of Prof. Felix Mottaghy

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May 3, 2017

Data based cardiac gating in rats and mice

During data-based cardiac gating available on the X-CUBE, the cardiac signal is derived from the data itself.

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April 29, 2017

Low dose ¹⁸F-NaF PET in mice

This application shows the possibility for full-body low-dow mouse PET-scanning on the β-CUBE.

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March 12, 2017

Dose reduction study with ^99mTc-DMSA

In this application we show the use of our γ-CUBE. The high-sensitivity, high-resolution SPECT imager allowing whole-body mouse and rat imaging. ^99mTc-DMSA is a SPECT tracer that is taken up in the cortex of the kidneys, and is used to assess renal function.

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March 2, 2017

Lung volume segmentation in mice

In this study, data based respiratory gated was performed after a high resolution CT acquisition. The end-enhalation and end-exhalation phases of the respiratory cycle were reconstructed.

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January 31, 2017

MOLECUBES PET/CT at UPENN, Philadelphia, USA

MOLECUBES has installed a PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN) at the lab of Prof. Joel Karp.

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January 1, 2017

Testimonial Prof. Dr. Christian Vanhove (BE)

Prof. Christian Vanhove is responsible for the day-to-day functioning of the preclinical INFINITY lab (Ghent, Belgium) and the coordination of the partner research, either from within Ghent University, from private pharma or biotech companies.

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May 29, 2016

MOLECUBES PET/SPECT/CT at Ghent University, Belgium

MOLECUBES has installed a PET/SPECT/CT benchtop combination at Ghent University's preclinical imaging lab, INFINITY. The lab is run by Prof. Christian Vanhove, is a consortium of research laboratories of the UGent University.

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October 25, 2015

Gamma-cube and X-cube: A New Scanner Generation for Benchtop Small Animal SPECT/CT (EANM, 2015)

The first generation small animal imaging systems offer molecular 3D imaging at sub millimetre spatial resolution with SPECT and sensitivities in the order of several percents using PET. These systems often occupy a whole room because they are based on large to medium-size detector technology, borrowed from clinical scanners.

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