March 16, 2020
Free Radical Research publication: S-nitrosylated l-serine-modified dendrimer as a kidney-targeting nitric oxide donor for prevention of renal ischaemia/reperfusion injury
γ-CUBE and X-CUBE were used to investigate the preventive effect of SNO-Ser-PAMAM on renal ischaemia/reperfusion injury
read more
March 11, 2020
PET/PET/CT at KULEUVEN
The Molecular Small Animal Imaging Center core facility (MoSAIC) at KU Leuven has significantly expanded its preclinical PET capability with a PET PET CT setup from MOLECUBES
read more
March 9, 2020
Imaging heart remodelling with [99mTc]MIBI in a rat model for stroke
cardiac imaging using SPECT
read more
March 9, 2020
Visualising the striatum with [123I]FP-CIT SPECT imaging
striata of a mouse brain with SPECT
read more
February 19, 2020
EANM2019 Abstract: Radiofluorinated gases as regional ventilation markers – Application to a rat model of acute lung inflammation
Radiofluorinated gases as regional ventilation markers - Application to a rat model of acute lung inflammation
read more
February 19, 2020
Evaluation of the biodistribution of [18F]-labeled carbon dots
Carbon dots are spherical, nontoxic, biocompatible and discrete particles that have gained tremendous interest over the last years because of their ultra-compact nanosize, favourable biocompatibility and versatile surface engineering properties. They show significant potential for use in cellular imaging, biosensing, targeted drug delivery, theranostics and other biomedical applications.
read more
February 18, 2020
Quantitative cardiac gated PET imaging
In cardiac research, non-invasive measurement of left ventricular end-systolic (ESV), end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) is a useful tool to evaluate and monitor cardiac function in health and disease.
read more
November 20, 2019
MOLECUBES Webinar – 11th of December 2019 – 16:00 CET
MOLECUBES Webinar December 2019 - Positive Impact of High Throughput Imaging on Preclinical Research - Dr. Unai Cossío will present on ongoing research at CIC biomaGUNE
read more
July 24, 2019
PET/CT at Ospedale San Raffaele
MOLECUBES and Radius have recently installed a preclinical benchtop whole body rat PET/CT in Milan (Italy) at San Raffaele Hospital and Scientific Institute, as a joint collaboration among the Institute of Molecular Bioimaging and Physiology of the Italian National Research Council (IBFM-CNR), San Raffaele Hospital and the Department of Medicine and Surgery of the University of Milan Bicocca.
read more
June 7, 2019
PET/SPECT/CT at Wiener Neustadt
MOLECUBES and Oncomed Solutions have recently installed a trimodal PET/SPECT/CT whole body rat and mouse benchtop preclinical imaging system at the University of Applied Sciences Wiener Neustadt, Austria.
read more
June 5, 2019
PET/SPECT/CT at CIC biomaGUNE
MOLECUBES installed a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at CIC biomaGUNE, San Sebastian, Spain.
read more
October 25, 2018
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
read more
October 25, 2018
β-CUBE at the University Hospital Basel
β-CUBE at the University Hospital Basel
read more
October 25, 2018
PET/SPECT/CT at University of Liverpool
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Liverpool
read more
October 12, 2018
Zebrafish PET-CT imaging
read more
October 12, 2018
Detection of atherosclerotic plaque inflammation with nanobodies – Need for high sensitivity and resolution
read more
October 12, 2018
Mouse femur imaging
read more
October 12, 2018
SPECT-CT imaging to monitor bone healing
read more
September 10, 2018
MOLECUBES installs SPECT CT at KPU, Japan
MOLECUBES has recently installed a SPECT/CT imaging solution at the Radioisotope Research Center of Kyoto Pharmaceutical University.
read more
September 7, 2018
18F-FDG PET-CT in a reumatoid arthritis model
18F-FDG PET-CT in a reumatoid arthritis model
read more
September 7, 2018
Brain imaging in rats and mice
PET-MR imaging provides unique and complimentary functional and anatomical information. The exceptional sensitivity of PET, combined with the excellent soft tissue contrast provided by MRI can be particularly beneficial when quantification of the PET signal requires delineating volumes of interest in an area where the CT image does not provide sufficient tissue contrast, e.g. in neurology applications.
read more
April 16, 2018
Lung imaging with SPECT-CT
read more
April 16, 2018
EMIM 2018 abstract: Nanoparticle imaging with CT
The aim of this study was to quantify x-ray image contrast induction that result from gold nanoparticles imaging.
read more
January 12, 2018
Biomaterials publication: Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
read more
November 29, 2017
In vivo visualisation of vessel formation in peritoneal tumor scaffolds with µCT – poster EMIM 2017
To study drug penetration and its influencing factors, reliable in vivo models that mimic peritoneal carcinomatosis are crucial. By applying tissue engineering we successfully biomimicked a peritoneal ovarian tumor and its environment in mice. Functional blood vessel formation was evaluated with contrast enhanced µCT.
read more
October 16, 2017
Thyroid imaging in mice
Radioiodine accumulation in thyroid tissues are well-established tools for managing patients with thyroid disease
read more
October 16, 2017
Low dose PET
The β-CUBE is able to detect very low levels of radioactivity, which can be important for evaluation of new PET radiotracers that were synthesised with a low radiochemical yield or low specific activity
read more
August 21, 2017
Application note: Influence of animal handling on [18F]FDG uptake
It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.
read more
August 18, 2017
Testimonial Prof. Dr. Joel Karp (USA)
The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.
read more
August 9, 2017
MOLECUBES SPECT/CT at BET Solutions, Athens, Greece
MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.
read more
August 1, 2017
Small footprint/high throughput: multiple mouse PET-CT imaging
High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.
read more
July 3, 2017
MOLECUBES PET/SPECT/CT at University of Chicago, USA
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.
read more
June 16, 2017
CT protocol comparison
Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface.
During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.
read more
June 6, 2017
The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)
To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.
read more
June 5, 2017
Dynamic 18F-FCA PET-CT in a mouse
18F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury
read more
June 2, 2017
Dynamic 18F-FDG PET-MR in a glioblastoma rat model
In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.
read more
June 1, 2017
Contrast enhanced CT to detect liver tumors in a HCC mouse model
The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.
read more
May 29, 2017
Multimodal imaging in an experimental rat model for brain metastasis (EMIM, 2017)
Metastatic brain tumors are a severe problem in the treatment of patients with breast carcinoma. We developed a rat model for brain metastasis that allows follow-up by MRI. Injection of cancer cells labeled with iron oxide particles, allows tracking from the single-cell stage until the appearance of full-blown metastases.
read more
May 25, 2017
MOLECUBES PET/CT at Universitätsklinikum Essen, Germany
MOLECUBES will install its PET/CT full body rat and mouse benchtop system at Universitätsklinikum Essen, Germany in the Preclinical Imaging Laboratory of Prof. Ken Herrmann.
read more
May 17, 2017
MOLECUBES SPECT/CT at Uniklinik RWTH Aachen, Germany
MOLECUBES will install a SPECT/CT full body rat and mouse benchtop combination at the Uniklinik RWTH Aachen, Germany in the preclinical imaging laboratory of Prof. Felix Mottaghy
read more
May 3, 2017
Data based cardiac gating in rats and mice
During data-based cardiac gating available on the X-CUBE, the cardiac signal is derived from the data itself.
read more
April 29, 2017
Low dose 18F-NaF PET in mice
This application shows the possibility for full-body low-dow mouse PET-scanning on the β-CUBE.
read more
March 12, 2017
Dose reduction study with 99mTc-DMSA
In this application we show the use of our γ-CUBE. The high-sensitivity, high-resolution SPECT imager allowing whole-body mouse and rat imaging. 99mTc-DMSA is a SPECT tracer that is taken up in the cortex of the kidneys, and is used to assess renal function.
read more
March 2, 2017
Lung volume segmentation in mice
In this study, data based respiratory gated was performed after a high resolution CT acquisition. The end-enhalation and end-exhalation phases of the respiratory cycle were reconstructed.
read more
January 31, 2017
MOLECUBES PET/CT at UPENN, Philadelphia, USA
MOLECUBES has installed a PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN) at the lab of Prof. Joel Karp.
read more
January 1, 2017
Testimonial Prof. Dr. Christian Vanhove (BE)
Prof. Christian Vanhove is responsible for the day-to-day functioning of the preclinical INFINITY lab (Ghent, Belgium) and the coordination of the partner research, either from within Ghent University, from private pharma or biotech companies.
read more
May 29, 2016
MOLECUBES PET/SPECT/CT at Ghent University, Belgium
MOLECUBES has installed a PET/SPECT/CT benchtop combination at Ghent University's preclinical imaging lab, INFINITY. The lab is run by Prof. Christian Vanhove, is a consortium of research laboratories of the UGent University.
read more
October 25, 2015
Gamma-cube and X-cube: A New Scanner Generation for Benchtop Small Animal SPECT/CT (EANM, 2015)
The first generation small animal imaging systems offer molecular 3D imaging at sub millimetre spatial resolution with SPECT and sensitivities in the order of several percents using PET. These systems often occupy a whole room because they are based on large to medium-size detector technology, borrowed from clinical scanners.
read more