November 20, 2019
MOLECUBES Webinar – 11th of December 2019 – 16:00 CET
MOLECUBES Webinar December 2019 - Positive Impact of High Throughput Imaging on Preclinical Research - Dr. Unai Cossío will present on ongoing research at CIC biomaGUNE
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July 24, 2019
PET/CT at Ospedale San Raffaele
MOLECUBES and Radius have recently installed a preclinical benchtop whole body rat PET/CT in Milan (Italy) at San Raffaele Hospital and Scientific Institute, as a joint collaboration among the Institute of Molecular Bioimaging and Physiology of the Italian National Research Council (IBFM-CNR), San Raffaele Hospital and the Department of Medicine and Surgery of the University of Milan Bicocca.
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June 7, 2019
PET/SPECT/CT at Wiener Neustadt
MOLECUBES and Oncomed Solutions have recently installed a trimodal PET/SPECT/CT whole body rat and mouse benchtop preclinical imaging system at the University of Applied Sciences Wiener Neustadt, Austria.
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June 5, 2019
PET/SPECT/CT at CIC biomaGUNE
MOLECUBES installed a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at CIC biomaGUNE, San Sebastian, Spain.
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October 25, 2018
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
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October 25, 2018
β-CUBE at the University Hospital Basel
β-CUBE at the University Hospital Basel
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October 25, 2018
PET/SPECT/CT at University of Liverpool
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Liverpool
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October 12, 2018
Zebrafish PET-CT imaging
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October 12, 2018
Detection of atherosclerotic plaque inflammation with nanobodies – Need for high sensitivity and resolution
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October 12, 2018
Mouse femur imaging
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October 12, 2018
SPECT-CT imaging to monitor bone healing
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September 10, 2018
MOLECUBES installs SPECT CT at KPU, Japan
MOLECUBES has recently installed a SPECT/CT imaging solution at the Radioisotope Research Center of Kyoto Pharmaceutical University.
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September 7, 2018
18F-FDG PET-CT in a reumatoid arthritis model
18F-FDG PET-CT in a reumatoid arthritis model
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September 7, 2018
Brain imaging in rats and mice
PET-MR imaging provides unique and complimentary functional and anatomical information. The exceptional sensitivity of PET, combined with the excellent soft tissue contrast provided by MRI can be particularly beneficial when quantification of the PET signal requires delineating volumes of interest in an area where the CT image does not provide sufficient tissue contrast, e.g. in neurology applications.
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April 16, 2018
Lung imaging with SPECT-CT
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April 16, 2018
EMIM 2018 abstract: Nanoparticle imaging with CT
The aim of this study was to quantify x-ray image contrast induction that result from gold nanoparticles imaging.
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January 12, 2018
Biomaterials publication: Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
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November 29, 2017
In vivo visualisation of vessel formation in peritoneal tumor scaffolds with µCT – poster EMIM 2017
To study drug penetration and its influencing factors, reliable in vivo models that mimic peritoneal carcinomatosis are crucial. By applying tissue engineering we successfully biomimicked a peritoneal ovarian tumor and its environment in mice. Functional blood vessel formation was evaluated with contrast enhanced µCT.
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October 16, 2017
Thyroid imaging in mice
Radioiodine accumulation in thyroid tissues are well-established tools for managing patients with thyroid disease
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October 16, 2017
Low dose PET
The β-CUBE is able to detect very low levels of radioactivity, which can be important for evaluation of new PET radiotracers that were synthesised with a low radiochemical yield or low specific activity
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August 21, 2017
Application note: Influence of animal handling on [18F]FDG uptake
It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.
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August 18, 2017
Testimonial Prof. Dr. Joel Karp (USA)
The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.
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August 9, 2017
MOLECUBES SPECT/CT at BET Solutions, Athens, Greece
MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.
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August 1, 2017
Small footprint/high throughput: multiple mouse PET-CT imaging
High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.
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July 3, 2017
MOLECUBES PET/SPECT/CT at University of Chicago, USA
MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.
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June 16, 2017
CT protocol comparison
Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface.
During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.
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June 6, 2017
The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)
To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.
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June 5, 2017
Dynamic 18F-FCA PET-CT in a mouse
18F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury
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June 2, 2017
Dynamic 18F-FDG PET-MR in a glioblastoma rat model
In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.
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June 1, 2017
Contrast enhanced CT to detect liver tumors in a HCC mouse model
The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.
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