APPLICATIONS – PUBLICATIONS

check out our latest installs, testimonials as well as an overview of our latest applications, abstracts and publications in PET, SPECT and CT. The menu below allows you to navigate through, or select parts of, the different sections.

October 16, 2017

Thyroid imaging in mice

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August 21, 2017

Application note: Influence of animal handling on [18F]FDG uptake

It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.
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August 18, 2017

Testimonial Prof. Dr. Joel Karp (USA)

The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.
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August 9, 2017

MOLECUBES SPECT/CT at BET Solutions, Athens, Greece

MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.
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August 1, 2017

Small footprint/high throughput: multiple mouse PET-CT imaging

High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.
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July 3, 2017

MOLECUBES PET/SPECT/CT at University of Chicago, USA

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.
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June 16, 2017

CT protocol comparison

Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface. During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.
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June 6, 2017

In vivo vertebra imaging in rats and mice

Preclinical models for musculoskeletal disorders are important for understanding the pathogenesis of bone and joint disorders in humans and to develop effective therapies. In vivo bone imaging studies on the X-CUBE allow the researcher to evaluate specific bones longitudinally in a non-invasive manner.
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June 6, 2017

The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)

To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.
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June 5, 2017

Dynamic 18F-FCA PET-CT in a mouse

18F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury
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June 2, 2017

Dynamic 18F-FDG PET-MR in a glioblastoma rat model

In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.
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June 1, 2017

Contrast enhanced CT to detect liver tumors in a HCC mouse model

The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.
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May 29, 2017

Multimodal imaging in an experimental rat model for brain metastasis (EMIM, 2017)

Metastatic brain tumors are a severe problem in the treatment of patients with breast carcinoma. We developed a rat model for brain metastasis that allows follow-up by MRI. Injection of cancer cells labeled with iron oxide particles, allows tracking from the single-cell stage until the appearance of full-blown metastases.
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May 25, 2017

MOLECUBES PET/CT at Universitätsklinikum Essen, Germany

MOLECUBES will install its PET/CT full body rat and mouse benchtop system at Universitätsklinikum Essen, Germany in the Preclinical Imaging Laboratory of Prof. Ken Herrmann.
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May 17, 2017

MOLECUBES SPECT/CT at Uniklinik RWTH Aachen, Germany

MOLECUBES will install a SPECT/CT full body rat and mouse benchtop combination at the Uniklinik RWTH Aachen, Germany in the preclinical imaging laboratory of Prof. Felix Mottaghy
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May 3, 2017

Data based cardiac gating in rats and mice

During data-based cardiac gating available on the X-CUBE, the cardiac signal is derived from the data itself.
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April 29, 2017

Low dose 18F-NaF PET in mice

This application shows the possibility for full-body low-dow mouse PET-scanning on the β-CUBE.
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March 12, 2017

Dose reduction study with 99mTc-DMSA

In this application we show the use of our γ-CUBE. The high-sensitivity, high-resolution SPECT imager allowing whole-body mouse and rat imaging. 99mTc-DMSA is a SPECT tracer that is taken up in the cortex of the kidneys, and is used to assess renal function.
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March 2, 2017

Lung volume segmentation in mice

In this study, data based respiratory gated was performed after a high resolution CT acquisition. The end-enhalation and end-exhalation phases of the respiratory cycle were reconstructed.
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January 31, 2017

MOLECUBES PET/CT at UPENN, Philadelphia, USA

MOLECUBES has installed a PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN) at the lab of Prof. Joel Karp.
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January 1, 2017

Testimonial Prof. Dr. Christian Vanhove (BE)

Prof. Christian Vanhove is responsible for the day-to-day functioning of the preclinical INFINITY lab (Ghent, Belgium) and the coordination of the partner research, either from within Ghent University, from private pharma or biotech companies.
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May 29, 2016

MOLECUBES PET/SPECT/CT at Ghent University, Belgium

MOLECUBES has installed a PET/SPECT/CT benchtop combination at Ghent University's preclinical imaging lab, INFINITY. The lab is run by Prof. Christian Vanhove, is a consortium of research laboratories of the UGent University.
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October 25, 2015

Gamma-cube and X-cube: A New Scanner Generation for Benchtop Small Animal SPECT/CT (EANM, 2015)

The first generation small animal imaging systems offer molecular 3D imaging at sub millimetre spatial resolution with SPECT and sensitivities in the order of several percents using PET. These systems often occupy a whole room because they are based on large to medium-size detector technology, borrowed from clinical scanners.
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