APPLICATIONS – PUBLICATIONS

Check out our latest installs, testimonials as well as an overview of our latest applications, abstracts and publications in PET, SPECT and CT. The menu below allows you to navigate through, or select parts of, the different sections.

October 25, 2018

PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)

PET/CT full body rat and mice set-up at the University of Pennsylvania (UPENN)
read more
October 25, 2018

PET/SPECT/CT at CIC biomaGUNE

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at CIC biomaGUNE
read more
October 25, 2018

β-CUBE at the University Hospital Basel

β-CUBE at the University Hospital Basel
read more
October 25, 2018

PET/SPECT/CT at University of Liverpool

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Liverpool
read more
October 12, 2018

Zebrafish PET-CT imaging

read more
October 12, 2018

Detection of atherosclerotic plaque inflammation with nanobodies – Need for high sensitivity and resolution

read more
October 12, 2018

Mouse femur imaging

read more
October 12, 2018

SPECT-CT imaging to monitor bone healing

read more
September 10, 2018

MOLECUBES installs SPECT CT at KPU, Japan

MOLECUBES has recently installed a SPECT/CT imaging solution at the Radioisotope Research Center of Kyoto Pharmaceutical University.
read more
September 7, 2018

18F-FDG PET-CT in a reumatoid arthritis model

18F-FDG PET-CT in a reumatoid arthritis model
read more
September 7, 2018

Brain imaging in rats and mice

PET-MR imaging provides unique and complimentary functional and anatomical information. The exceptional sensitivity of PET, combined with the excellent soft tissue contrast provided by MRI can be particularly beneficial when quantification of the PET signal requires delineating volumes of interest in an area where the CT image does not provide sufficient tissue contrast, e.g. in neurology applications.
read more
April 16, 2018

Lung imaging with SPECT-CT

read more
April 16, 2018

EMIM 2018 abstract: Nanoparticle imaging with CT

The aim of this study was to quantify x-ray image contrast induction that result from gold nanoparticles imaging.
read more
January 12, 2018

Biomaterials publication: Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo

read more
November 29, 2017

In vivo visualisation of vessel formation in peritoneal tumor scaffolds with µCT – poster EMIM 2017

To study drug penetration and its influencing factors, reliable in vivo models that mimic peritoneal carcinomatosis are crucial. By applying tissue engineering we successfully biomimicked a peritoneal ovarian tumor and its environment in mice. Functional blood vessel formation was evaluated with contrast enhanced µCT.
read more
October 16, 2017

Thyroid imaging in mice

Radioiodine accumulation in thyroid tissues are well-established tools for managing patients with thyroid disease
read more
October 16, 2017

Low dose PET

The β-CUBE is able to detect very low levels of radioactivity, which can be important for evaluation of new PET radiotracers that were synthesised with a low radiochemical yield or low specific activity
read more
August 21, 2017

Application note: Influence of animal handling on [18F]FDG uptake

It has been demonstrated that the animal handling protocol might influence 18F-FDG uptake in rodents. Therefore, it is important to evaluate the animal handling protocol during study set up. This application note gives an overview of the different animal handling protocols and their outcomes.
read more
August 18, 2017

Testimonial Prof. Dr. Joel Karp (USA)

The Small Animal Imaging Facility (SAIF) provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals, primarily mice and rats, but also primates.
read more
August 9, 2017

MOLECUBES SPECT/CT at BET Solutions, Athens, Greece

MOLECUBES will install SPECT/CT whole-body rat and mouse benchtop imagers at BET Solutions, Athens, Greece.
read more
August 1, 2017

Small footprint/high throughput: multiple mouse PET-CT imaging

High-throughput multi-mouse imaging can be easily done using our rat bed and mouse hotel. Up to 4 mice can be imaged simultaneously.
read more
July 3, 2017

MOLECUBES PET/SPECT/CT at University of Chicago, USA

MOLECUBES will install a PET/SPECT/CT whole-body rat and mouse benchtop imaging solution at the University of Chicago, USA, in the Integrated Small Animal Imaging Research Resource (iSAIRR) core facility.
read more
June 16, 2017

CT protocol comparison

Operating the systems is made very simple and intuitive thanks to the MOLECUBES graphical user interface. During X-CUBE study set-up, the user can choose between 3 programmed protocols: high resolution, general purpose and high throughput. With every selection, the user can also opt for reduced dose scanning.
read more
June 6, 2017

The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging (SNMMI, 2017)

To further improve preclinical PET, new systems should improve spatial resolution and sensitivity. Ideally this is obtained without increasing the total cost of the system. Based on monolithic scintillators with highly sampled readout and Depth-Of-Interaction capability, MOLECUBES developed a compact preclinical PET system, called the β-CUBE. Here, we report on the design, the specifications, performance evaluation and in-vivo imaging results.
read more
June 5, 2017

Dynamic 18F-FCA PET-CT in a mouse

18F-FCA is a radiolabeled bile acid analogue which can be used to visualize hepatobiliary transport (De Lombaerde et al., 2017, Plos One). Several drugs are inhibitor of the involved transporters, which can lead to severe drug induced liver injury
read more
June 2, 2017

Dynamic 18F-FDG PET-MR in a glioblastoma rat model

In this application we show the possibilities for high-resolution brain imaging and compatibility of our β-CUBE with preclinical MR-systems.
read more
June 1, 2017

Contrast enhanced CT to detect liver tumors in a HCC mouse model

The X-CUBE is ultimately suited for contrast enhanced anatomical studies in both rat and mouse. In this case, contrast enhanced CT was done to evaluate liver tumors in a hepatocellular carcinoma (HCC) mouse model.
read more
May 29, 2017

Multimodal imaging in an experimental rat model for brain metastasis (EMIM, 2017)

Metastatic brain tumors are a severe problem in the treatment of patients with breast carcinoma. We developed a rat model for brain metastasis that allows follow-up by MRI. Injection of cancer cells labeled with iron oxide particles, allows tracking from the single-cell stage until the appearance of full-blown metastases.
read more
May 25, 2017

MOLECUBES PET/CT at Universitätsklinikum Essen, Germany

MOLECUBES will install its PET/CT full body rat and mouse benchtop system at Universitätsklinikum Essen, Germany in the Preclinical Imaging Laboratory of Prof. Ken Herrmann.
read more
May 17, 2017

MOLECUBES SPECT/CT at Uniklinik RWTH Aachen, Germany

MOLECUBES will install a SPECT/CT full body rat and mouse benchtop combination at the Uniklinik RWTH Aachen, Germany in the preclinical imaging laboratory of Prof. Felix Mottaghy
read more